Stress-induced brain-mediated immunoregulation is effected by two path
ways: autonomic outflow and (neuro)endocrine outflow. Particular atten
tion is given to the interaction-effects of chronic an acute stress. R
ecent data have established that cells of the immune system produce ne
uro-peptides and hormones. In concert with cytokines released by these
immune cells the brain can be informed on the nature of ongoing immun
e activity. The significance of conditioning of immune responses is di
scussed.