URAZOLE-BRIDGED BICYCLIC AZOALKANES - GENERATION, NITROXYL TRAPPING, AND ESR-SPECTRA OF THE HETEROSUBSTITUTED 4,5-DIAZA-1,3-CYCLOPENTANEDIYL DIRADICALS THROUGH DIRECT AND BENZOPHENONE-SENSITIZED PHOTOCHEMICAL DEAZETATION
W. Adam et al., URAZOLE-BRIDGED BICYCLIC AZOALKANES - GENERATION, NITROXYL TRAPPING, AND ESR-SPECTRA OF THE HETEROSUBSTITUTED 4,5-DIAZA-1,3-CYCLOPENTANEDIYL DIRADICALS THROUGH DIRECT AND BENZOPHENONE-SENSITIZED PHOTOCHEMICAL DEAZETATION, Journal of organic chemistry, 60(2), 1995, pp. 308-316
The Diels-Alder reaction of isopyrazoles 3 with 4-methyl-1,2,4-triazol
ine-3,5-dione afforded the azoalkanes 4 in high yields. The stereochem
istry of the syn- and anti-diastereomeric derivatives 4b was establish
ed on the basis of spectral data and an X-ray structure determination
for syn-4b. Photochemical loss of dinitrogen through direct as well as
benzophenone-sensitized photolysis led to the corresponding housanes
5. For the stereolabeled syn- and anti-4b azoalkanes, the respective h
ousanes anti- and syn-5b were obtained as mixtures, the latter in pref
erence (syn/anti > 90:10). Above -10 degrees C, the housanes 5b isomer
ized thermally to a 96:4 (at -30 degrees C) thermodynamic mixture of s
yn/anti, for which a van't Hoff treatment gave Delta G(243 K) = -4.4 k
J/mol in favor of syn-5b, Delta H = 4.2 kJ/mol, and Delta S = 36 J/mol
K. AM1 calculations confirm that the syn-fib diastereomer is the pref
erred one. The triplet-sensitized photolysis at -30 degrees C of the s
eparate syn- and anti-4b azoalkanes gave the same thermodynamically co
ntrolled mixture of housanes 5b (syn/anti = 96:4), which speaks for a
planar triplet 1,3 diradical T-IIb as intermediate. The intervention o
f triplet diradicals T-IIa,d was confirmed by ESR spectroscopy under m
atrix isolation (T less than or equal to 77 K), and the triplet ground
state was established by a Curie plot for the dimethyl derivative T-I
Ia. Since in the direct photolysis of the separate syn- and anti-4b az
oalkanes also predominantly the syn-5b housane was obtained, fast inte
rsystem crossing of the singlet 1,3 diradical S-IIb to the triplet spe
cies T-IIb is proposed. The small memory effect (retention) in the dir
ect photolysis in solution implies a puckered conformation for the sin
glet 1,3 diradical S-IIb. Indeed, in the direct deazetation under matr
ix conditions at -78 degrees C, the memory effect (retention) is unequ
ivocally established, i.e. syn/anti-5b = 24:76 for azoalkane syn-4b an
d syn/anti > 99:1 for anti-4b. In the presence of the nitroxyl radical
scavenger 1,1,3,3-tetramethylisoindolin-2-yloxyl, the 1,3 diradicals
were efficiently trapped in form of the isomeric bis-alkoxyamines 7 in
the triplet-sensitized as well as direct photolyses of azoalkanes 4a,
d. These unprecedented results imply that heteroatom substitution does
not generally reduce the lifetime of triplet diradicals.