ENYNONES IN ORGANIC-SYNTHESIS .8. SYNTHESIS OF THE ANTIMICROBIAL-CYTOTOXIC AGENT JUNCUSOL AND MEMBERS OF THE EFFUSOL CLASS OF PHENOLS

Authors
JACOBI PA KRAVITZ JI ZHENG WJ
Citation
Pa. Jacobi et al., ENYNONES IN ORGANIC-SYNTHESIS .8. SYNTHESIS OF THE ANTIMICROBIAL-CYTOTOXIC AGENT JUNCUSOL AND MEMBERS OF THE EFFUSOL CLASS OF PHENOLS, Journal of organic chemistry, 60(2), 1995, pp. 376-385
Citations number
49
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of organic chemistry → ACNP
ISSN journal
00223263
Volume
60
Issue
2
Year of publication
1995
Pages
376 - 385
Database
ISI
SICI code
0022-3263(1995)60:2<376:EIO.SO>2.0.ZU;2-U
Abstract
Two new syntheses of phenols have been developed which have been utili zed in an efficient preparation of the antimicrobial-cytotoxic agent j uncusol (22) and several members of the effusol (23) class of phenols. These results complement our earlier studies with enynones of type 42 and provide for the highly efficient conversion of 42 to either methy lenecyclopentenones 45 or phenols of type 47 or 54 with virtually 100% selectivity.