STEREOCHEMISTRY OF AN 18,22-CYCLOSTEROL, MER-NF8054X, FROM EMERICELLA-HETEROTHALLICA AND ASPERGILLUS-USTUS

Authors
MIZUNO R KAWAHARA N NOZAWA K YAMAZAKI M NAKAJIMA S KAWAI K
Citation
R. Mizuno et al., STEREOCHEMISTRY OF AN 18,22-CYCLOSTEROL, MER-NF8054X, FROM EMERICELLA-HETEROTHALLICA AND ASPERGILLUS-USTUS, Chemical and Pharmaceutical Bulletin, 43(1), 1995, pp. 9-11
Citations number
6
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
43
Issue
1
Year of publication
1995
Pages
9 - 11
Database
ISI
SICI code
0009-2363(1995)43:1<9:SOA1MF>2.0.ZU;2-A
Abstract
An 18,22-cyclosterol, Mer-NF8054X (1), first isolated from a shaken cu lture of Aspergillus ustus as a strong antifungal agent with activity against Aspergillus fumigatus, was isolated from the culture filtrate of Emericella heterothallica. The absolute structure of 1 was establis hed as 11-oxo-18,22-cycloergosta-6,8(14)-diene-3 beta,5 beta,9 beta,23 S-tetraol by spectroscopic and chemical investigation, and X-ray cryst allographic analysis.