APPLICATION OF AN ORIGINAL PROCESS FOR OBTAINING COLLOIDAL DISPERSIONS OF SOME COATING POLYMERS - PREPARATION, CHARACTERIZATION, INDUSTRIALSCALE-UP

Authors
DELABOURET A THIOUNE O FESSI H DEVISSAGUET JP PUISIEUX F
Citation
A. Delabouret et al., APPLICATION OF AN ORIGINAL PROCESS FOR OBTAINING COLLOIDAL DISPERSIONS OF SOME COATING POLYMERS - PREPARATION, CHARACTERIZATION, INDUSTRIALSCALE-UP, Drug development and industrial pharmacy, 21(2), 1995, pp. 229-241
Citations number
9
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Drug development and industrial pharmacy → ACNP
ISSN journal
03639045
Volume
21
Issue
2
Year of publication
1995
Pages
229 - 241
Database
ISI
SICI code
0363-9045(1995)21:2<229:AOAOPF>2.0.ZU;2-I
Abstract
An original process for obtaining colloidal dispersions were used to p repare pseudolatex of coating polymers (Eudragit E 100 and Eudragit S 100). The method consists in introducing under magnetic stirring; a so lution of the polymers in a water-miscible solvent into an aqueous sol ution containing surfactant. In these conditions, polymers precipitate spontaneously in nanospheres. Investigations of some manufacturing pa rameters (initial polymer concentration, nature and concentration of s urfactant) have allowed development of formulae for a semi-industrial scal-up. Characteristics of dispersions were also determined.