COURSE OF IDIOPATHIC THROMBOCYTOPENIC PUR PURA (ITP) AFTER TREATMENT WITH MAPROTILINE

Citation
F. Konig et al., COURSE OF IDIOPATHIC THROMBOCYTOPENIC PUR PURA (ITP) AFTER TREATMENT WITH MAPROTILINE, Nervenarzt, 66(1), 1995, pp. 60-65
Citations number
31
Categorie Soggetti
Psychiatry,Neurosciences
Journal title
ISSN journal
00282804
Volume
66
Issue
1
Year of publication
1995
Pages
60 - 65
Database
ISI
SICI code
0028-2804(1995)66:1<60:COITPP>2.0.ZU;2-3
Abstract
Whereas leucocytopenia is reported to be a relatively frequent side-ef fect of treatment with tricyclic and tetracyclic antidepressants and a typical neuroleptic agents, isolated thrombocytopenias are rare. To ou r knowledge there are no reports of thrombocytopenia in connection wit h the tetracyclic antidepressant maprotiline. This report describes th e case of a 53-year-old female patient with neurotic depression and an initially unsuspected chronic idiopathic thrombocytopenic purpura (IT P). Following previous treatment with an angiotensin-converting enzyme inhibitor, cilazapril, and an estrogen derivative, the patient develo ped an episode of the ITP after beginning treatment with maprotiline. The possible aetiology and the course of the illness are discussed.