DETECTION OF SUPPORTED LIPID LAYERS WITH THE ACOUSTIC LOVE WAVE-GUIDEDEVICE - APPLICATION TO BIOSENSORS

The formation of supported lipid mono- and bilayers on a thiol-coated surface was monitored by utilising the acoustic Love waveguide device. The detection of the lipid layers was used as a model system for rela ting the phase response to the deposited mass and studying the sensor' s response to the regeneration of the surface. The sensitivity of the acoustic device revealed that, in addition to the mass change occurrin g during the deposition of the lipid layers, the viscoelastic properti es of the interface change significantly. Finally, a biosensor system was studied, where the antigen was self-assembled on the device surfac e and the binding and further displacement of its complementary antibo dy monitored.