CONSISTENT PRESENCE OF ISOCHROMOSOME-7Q IN HEPATOSPLENIC T-GAMMA DELTA-LYMPHOMA - A NEW CYTOGENETIC-CLINICOPATHOLOGICAL ENTITY/

Peripheral T-cell lymphoma (PTL), which is characterized by hepatosple nic presentation and the gamma/delta T-cell receptor (TCR) phenotype o n the malignant cells, is a rare but distinct subtype of non-Hodgkin's lymphomas. Little is known about the chromosomal changes in these lym phomas. We report the cytogenetic analysis of three patients who had n eoplastic proliferation of T gamma/delta cells in the spleen, bone mar row, and liver, but not in lymph nodes or skin. Isochromosome 7q and t risomy 8 were observed in all three patients. Isochromosome 7q as the sole abnormality has been previously reported in one patient with simi lar clinicopathologic features. It is suggested that i(7q) is a primar y, nonrandom chromosomal abnormality in hepatosplenic T gamma/delta PT L. (C) 1995 Wiley-Liss, Inc.