METHOD FOR MEASURING AQUEOUS SOLUBILITIES OF ORGANIC-COMPOUNDS

A new and simple method for the determination of the aqueous solubilit y expressed in grams per gram of solution of organic compounds is pres ented. A saturated aqueous solution is generated within a dialysis tub ing at 25.0 +/- 0.2 degrees C. As demonstrated with cyclohexanol (wate r solubility around 3.8%) and anthracene (water solubility around 50 p pb) equilibrium is reached within 24 h. The concentration of the organ ic compounds in the aqueous solutions was determined via gas chromatog raphy, which allows the measurement of samples that contain impurities or tend to degrade during measurement with high accuracy. Comparison of the solubility data for a series of organic compounds collected fro m the literature with the values obtained with the method described he rein demonstrates its reliability. Thus, the method described allows t he determination of water solubilities of organic compounds within a r ange from percent to the ppb region with a high accuracy and precision in a simple and efficient way.