EXPERIMENTAL-STUDY ON CHEMOTHERAPY USING ADSORBENT CHARCOAL WITH CDDPADMINISTERED DIRECTLY INTO THE MEDIASTINUM FOLLOWING ESOPHAGECTOMY

In this study, 1500AA, an activated charcoal with a strong affinity fo r the lymphatic system, was examined for its ability to deliver chemot herapy to metastatic lymph nodes. First, the anticancer effect on meta static lymph nodes was assessed in an experiment using the mouse mamma ry tumor, MM48. Pathological examination of the inguinal lymph nodes r evealed a metastatic rate of 50% in the group given cisplatin (CDDP)-s aline, but 20% in the group given CDDP-charcoal. Next, in a canine mod el, CDDP dissolved in normal saline was administered directly into the mediastinum, and CDDP was given with fine particles of activated char coal in the same manner in the other group. The concentration of CDDP in the lymph nodes and the plasma rapidly increased to peak in 10 min in the CDDP-saline group, whereas it increased slowly to peak in 20-30 min in the CDDP-charcoal group. Moreover, the CDDP-charcoal group was found to have a much higher concentration of CDDP in the lymph nodes than the CDDP-saline group.