TUMOR-NECROSIS-FACTOR PRODUCTION AND COLON-CANCER

Tumor necrosis factor (TNF) production in B10 mice exhibiting H-2 gene heterogeneity and in C3H/ He mice differing in lipopolysaccharide (LP S) responsiveness was investigated following stimulation with OK-432. TNF-producing capacity in these mice was H-2-restricted, while their L PS responsiveness was independent of the gene. TNF production in human s was found to be HLA-B antigen-restricted. An investigation was then made of the effect of endogenous TNF induction with OK-432 on the surv ival rate of colorectal cancer patients. Patients in the TNF-producing group showed a trend toward having a better prognosis as compared to those in the TNF-nonproducing group. Cancer therapy formulated with co nsideration of host responsiveness to OK-432 may afford greater therap eutic benefit and may prolong survival.