Js. Sartin et Ho. Perry, FROM MERCURY TO MALARIA TO PENICILLIN - THE HISTORY OF THE TREATMENT OF SYPHILIS AT THE MAYO-CLINIC - 1916-1955, Journal of the American Academy of Dermatology, 32(2), 1995, pp. 255-261
Between 1916 and 1955 the Mayo Clinic became recognized as one of the
premier institutions specializing in the treatment of syphilis. First
under the direction of John H. Stokes (1916-1924) and later Paul A. O'
Leary (1924-1953), its Department of Dermatology and Syphilology, toge
ther with the members of the Clinical Cooperative Study Group, oversaw
the establishment of standardized methods for the administration of t
he existing arsenicals and the introduction of new therapies. Malaria
therapy, heat therapy, penicillin, and oxytetracycline each represente
d important advances in the treatment of syphilis and were extensively
evaluated. Two important ancillary benefits of syphilis treatment wer
e the development of routine intravenous techniques, which would later
prove invaluable for the administration of antibiotics and cancer dru
gs, and the establishment of large cooperative clinical trials, the fi
rst of their kind. Under the leadership of Stokes and O'Leary the depa
rtment produced a stream of pivotal clinical research that contributed
to the effective management of syphilis in the United States.