EFFECTS OF 5-HT3 RECEPTOR ANTAGONISTS ON MODELS OF ACUTE AND DELAYED EMESIS INDUCED BY CISPLATIN IN THE FERRET

Authors
RUDD JA NAYLOR RJ
Citation
Ja. Rudd et Rj. Naylor, EFFECTS OF 5-HT3 RECEPTOR ANTAGONISTS ON MODELS OF ACUTE AND DELAYED EMESIS INDUCED BY CISPLATIN IN THE FERRET, Neuropharmacology, 33(12), 1994, pp. 1607-1608
Citations number
5
Categorie Soggetti
Pharmacology & Pharmacy",Neurosciences
Journal title
Neuropharmacology → ACNP
ISSN journal
00283908
Volume
33
Issue
12
Year of publication
1994
Pages
1607 - 1608
Database
ISI
SICI code
0028-3908(1994)33:12<1607:EO5RAO>2.0.ZU;2-6
Abstract
The emetic profile of action of cisplatin 5 and 10 mg/kg i.p. was inve stigated in the ferret over a 72 and 24hr period respectively. The 5-H T3 receptor antagonists ondansetron and alosetron markedly antagonized or abolished the emesis during the ''acute phase'' and, whilst antago nizing the emesis during the delayed phase, also revealed a 5-HT3 rece ptor antagonist resistant component. These cisplatin paradigms may pro vide models relevant to the study of acute and delayed emesis induced by cisplatin in man.