USE OF ENDOGENOUS PHOTOSENSITIZERS (CHROM OPHORES) TO IMPROVE THE EFFICACY OF SELECTIVE PHOTOTHERAPY OF PSORIASIS PATIENTS .1. EFFICACY ANDMECHANISMS OF ACTION

Authors
OLISOVA MO AKIMOV VG KUBANOVA AA
Citation
Mo. Olisova et al., USE OF ENDOGENOUS PHOTOSENSITIZERS (CHROM OPHORES) TO IMPROVE THE EFFICACY OF SELECTIVE PHOTOTHERAPY OF PSORIASIS PATIENTS .1. EFFICACY ANDMECHANISMS OF ACTION, Vestnik dermatologii i venerologii, (6), 1994, pp. 10-12
Citations number
23
Categorie Soggetti
Dermatology & Venereal Diseases
Journal title
Vestnik dermatologii i venerologii → ACNP
ISSN journal
00424609
Issue
6
Year of publication
1994
Pages
10 - 12
Database
ISI
SICI code
0042-4609(1994):6<10:UOEP(O>2.0.ZU;2-7
Abstract
Studies of the effect of UV exposure in the presence of potential chro mophores (pyridoxal phosphate and nicotinamide) on the intensity of ch emiluminescence of polymorphonuclear leukocytes revealed a marked incr ease of chemiluminescence by 12 and 21%, respectively, when preirradia ted aqueous solutions of drugs were introduced in the model system. A possible mechanism of the effect of endogenous photosensitizers in com bination with selective phototherapy of psoriasis patients, leading to inhibition of the proliferative activity of the epidermis, is discuss ed.