GASTRIC-MUCOSAL PHOSPHOLIPIDS IN DOGS WITH FAMILIAL STOMATOCYTOSIS-HYPERTROPHIC GASTRITIS

In dogs, hypertrophic gastritis, which resembles Menetrier's disease i n man, has been demonstrated to be part of a hereditary syndrome calle d familial stomatocytosis-hypertrophic gastritis. In addition to hyper trophic gastritis, affected dogs exhibit abnormal blood phospholipid c omposition. Phospholipids may play a role in maintaining gastric mucos al integrity, and this may be compromised in gastritis. The question a rises whether the differences in blood phospholipids may result from a disorder that might also be revealed in the composition of gastric mu cosal phospholipids. We analysed the phospholipid composition of gastr ic mucosa from four dogs With familial stomatocytosis-hypertrophic gas tritis. The general phospholipid composition and the molecular composi tion of phosphatidylcholine from mucosal tissue in the corpus of the s tomach where hypertrophic gastritis was evident were not different fro m that of the antrum, where the tissue was normal. These results do no t corroborate a relation between the gastric mucosal phospholipid comp osition and hypertrophic gastritis.