The genetic familial register in question contains information on 441
hemophilia patients. Two-thirds of the patients suffered from moderate
or severe hemophilia, 81.3% had hemophilia A. Fifty-two families with
the latter disease were examined with molecular methods which confirm
ed heterozygous carriage in 40% of the female examinees. The prenatal
diagnosis in two families led to delivery of healthy boys. The genetic
register provides effective protection for hemophiliac families.