DRUG-RESISTANCE OF MYCOBACTERIUM-TUBERCULOSIS STRAINS ISOLATED FROM HIV-INFECTED ITALIAN PATIENTS - PRELIMINARY-REPORT FROM A MULTICENTRIC STUDY

Authors
ANGARANO G CARBONARA D COSTA D AZZINI M MANTIA E AMENDOLA G CARACCIO W SCALISE G GIACOMETTI A BURZACCHINI F PIERSIMONI C MAZZOTTA F BLANC PL LOCAPUTO S CARBONARA S ROLLO M PASTORE G BARBUTI S GRIMALDI A CHIODO F COSTIGLIOLA P NANETTI A GRITTI FM BINI A DIPEDE C CAROSI G MATTEELLI A PINSI G FERRARO T PRIAMO A FOCA A GHINELLI F LIBANORE M ROSSI MR LEONCINI F ROGASI PG STERRANTINO G TORTOLI E GIANNELLI F ERRANTE I CAGGESE L ASTOLFI A LAZZARIN A MORO M VAIANI R MANTELLINI P BESOZZI G PENATI V MORONI M GORI A SALVAGGIO L TOCALLI L MILAZZO F VIGEVANI GM QUIRINO T NARDI C CARGNEL A DEDIVITIIS GF PIAZZA M CHIRIANNI A DABBRACCIO M CADROBBI P MENEGHETTI F BERTIATO G ROSS L PAULUZZI S PASTICCI MB BISTONI F ALBERICI F VIALE P CONFALONIERI M CAVATORTA E RICCIO G SANTORIELLO L BONAZZI L GIUDICI MG MORINI C GIANNINI V GHIRGA P BORDI E PANICHI G BABUDIERI S SARAIS S FADDA G BAGEDDA L GIOANNINI P SINICCO A PONCINI L MILANO R GRILLONE W GAIOTTINO F SORANZO ML NIGRA E BUSSO M VEGLIO V PANERO P DELALLA F PELLIZZER GP FABRIS P SCAGNELLI M ANTONUCCI G GIRARDI E IPPOLITO G
Citation
G. Angarano et al., DRUG-RESISTANCE OF MYCOBACTERIUM-TUBERCULOSIS STRAINS ISOLATED FROM HIV-INFECTED ITALIAN PATIENTS - PRELIMINARY-REPORT FROM A MULTICENTRIC STUDY, The New microbiologica, 18(1), 1995, pp. 69-72
Citations number
NO
Categorie Soggetti
Microbiology
Journal title
The New microbiologica
ISSN journal
11217138 → ACNP
Volume
18
Issue
1
Year of publication
1995
Pages
69 - 72
Database
ISI
SICI code
1121-7138(1995)18:1<69:DOMSIF>2.0.ZU;2-W
Abstract
A multicentric prospective study started in March '93 to describe both initial and acquired resistance of Mycobacterium Tuberculosis in Ital ian HIV+ patients (Pyrazinamide (pts.) to first line drugs: Rifampin ( R), Isoniazid (I), Pyrazinamide (P), Ethambutol (E), Streptomycin (S). All tuberculosis (TB) cases diagnosed in HIV+ patients (pts.) were in cluded, along with clinical-anamnestical data. Drug-susceptibility tes ts were performed centrally. Preliminary results indicate an overall l ow frequency of TB resistance to first line drugs: R=2%, P=4%, S=9%, I /E=none. However, a relevant nosocomial outbreak of multiple drug resi stant (DR) TB was detected. This finding, along with some previous Ita lian reports of DR-TB clusters, may herald a further spread of DR-TB. Surveillance, therefore, is mandatory in Italy from now on.