IMMUNOPATHOLOGY OF EXPERIMENTAL JEMBRANA DISEASE IN BALI CATTLE

Sequential immunohistochemical studies of the lymphoreticular response s of Bali cattle (Bos javanicus syn. Bos sondaicus) after inoculation with the Jembrana disease virus were carried out using the peroxidase- antiperoxidase test for immunoglobulin containing cell assessment and the indirect immunoperoxidase test for lymphocyte subset assessment. T he prevalence of immunoglobulin G-containing cells declined during the acute phase of the disease but became significantly elevated during c onvalescence. This trend was consistent with serological responses pre viously observed using an enzyme linked immunosorbent assay. Temporary immunosuppression appeared to occur during the acute phase of the dis ease as indicated by a decrease in the immunoglobulin G-containing cel ls in the lymphoid organs and an observed decrease in the BoCD4/BoCD8 lymphocyte ratio in lymph node follicles.