SELECTIVE RECONSTITUTION OF CD8-LYMPHOCYTE RESPONSES IN IMMUNODEFICIENT BONE-MARROW TRANSPLANT RECIPIENTS BY THE ADOPTIVE TRANSFER OF T-CELL CLONES( CYTOTOXIC T)

Authors
RIDDELL SR WALTER BA GILBERT MJ GREENBERG PD
Citation
Sr. Riddell et al., SELECTIVE RECONSTITUTION OF CD8-LYMPHOCYTE RESPONSES IN IMMUNODEFICIENT BONE-MARROW TRANSPLANT RECIPIENTS BY THE ADOPTIVE TRANSFER OF T-CELL CLONES( CYTOTOXIC T), Bone marrow transplantation, 14, 1994, pp. 78-84
Citations number
39
Categorie Soggetti
Hematology,Oncology,Immunology,Transplantation
Journal title
Bone marrow transplantation → ACNP
ISSN journal
02683369
Volume
14
Year of publication
1994
Supplement
4
Pages
78 - 84
Database
ISI
SICI code
0268-3369(1994)14:<78:SROCRI>2.0.ZU;2-N
Abstract
The adoptive transfer of T cells specific for antigens encoded by path ogens and tumors has been an effective treatment for infections and ma lignancies in animal models and is potentially applicable for infectio ns occurring in immunodeficient bone marrow transplant recipients. Thi s article reviews recent insights derived from studies of the immunobi ology of human cytomegalovirus (CMV) infection in healthy and immunode ficient hosts and the development of adoptive immunotherapy as prophyl axis for CMV infection in recipients of allogeneic bone marrow transpl ants.