NOVEL CONTRAST AGENTS FOR MAGNETIC-RESONANCE-IMAGING - SYNTHESIS AND CHARACTERIZATION OF THE LIGAND BOPTA AND ITS LN(III) COMPLEXES (LN=GD,LA, LU) - X-RAY STRUCTURE OF DISODIUM A-5,8,11-TRIAZATRIDECAN-13-OATO(5-)]GADOLINATE(2-) IN A MIXTURE WITH ITS ENANTIOMER
F. Uggeri et al., NOVEL CONTRAST AGENTS FOR MAGNETIC-RESONANCE-IMAGING - SYNTHESIS AND CHARACTERIZATION OF THE LIGAND BOPTA AND ITS LN(III) COMPLEXES (LN=GD,LA, LU) - X-RAY STRUCTURE OF DISODIUM A-5,8,11-TRIAZATRIDECAN-13-OATO(5-)]GADOLINATE(2-) IN A MIXTURE WITH ITS ENANTIOMER, Inorganic chemistry, 34(3), 1995, pp. 633-642
The syntheses of the ligand BOPTA, ethyl)-1-phenyl-2-oxa-5,8,11-triaza
tridecan-13-oic acid; benic acid) and its Gd(III), La(III), and Lu(III
) complexes are reported. Protonation constants for BOPTA have been de
termined by potentiometry, and the microscopic protonation sequence ha
s been investigated by H-1 NMR. The results obtained together with the
value of the Gd-BOPTA(2-) stability constant (log K-ML = 22.59) show
that the complexing properties of the ligand, in comparison with DTPA,
are little affected by the presence of the benzyloxymethyl residue in
the structure. The solid state:structure of Gd-BDPTA disodium salt [C
22H26N3O11(H2O)Gd]Na-2(3)/2H2O was determined in a single-crystal X-ra
y diffraction study; The structure consists of [C22H26N3O11(H2O)Gd](2-
) anions, sodium cations, and water molecules; the space group is P (1
) over bar (Z = 2), with a = 9.083(6) Angstrom, b = 9.469(2) Angstrom,
c = 16.698(6) Angstrom, alpha = 102.22(3)degrees, beta = 92.48(4)degr
ees, gamma = 102.26(3)degrees, V = 1366(1) Angstrom(3), d = 1.84 g/mL.
The gadolinium ion adopts a nine-coordinate geometry, which is best d
escribed as a distorted tricapped trigonal prism: Eight coordinating s
ites are occupied by the ligand (three nitrogen atoms and five carboxy
late oxygens), and the ninth site is occupied by the oxygen atom of a
water molecule. Relaxation studies have shown that in solution also Gd
-BOPTA(2-) has one water molecule directly coordinated to the metal io
n; La-139 MMR studies on the La-BOPTA(2-) complex have further support
ed the view that such-complexes maintain in solution the same kind of
coordination as found in the solid state for Gd-BOPTA disodium salt. C
-13 NMR spectra of the diamagnetic La- and Lu-BOPTA(2-) complexes at v
arious temperatures are consistent with the presence of two couples of
isomers interconverting through a dynamic process. Such a process has
previously been reported for the parent Ln-DTPA(2-) complexes.