A CLINICAL AND IMMUNOHISTOCHEMICAL STUDY OF PAPILLARY ADENOCARCINOMA OF THE PROSTATE

Clinical and immunohistochemical studies were conducted to evaluate pr ostatic papillary adenocarcinoma and prostatic papillary hyperplasia. Subjects consisted of 5 cases of papillary adenocarcinoma and 2 cases of papillary hyperplasia. There is no conclusive clinical factor for p reoperative diagnosis, but we attach importance to endoscopic findings . PSA, PAP, high molecular weight cytokeratin, and PCNA were evaluated immunohistochemically. PSA became positive in every instance but one- a case of papillary adenocarcinoma which became +/-.PAP was + in all c ases, except for 1 case of papillary adenocarcinoma. Basal cells were positive for high molecular weight cytokeratin in 2 cases of papillary hyperplasia but were missing in papillary adenocarcinoma. Although PC NA was free from positive nuclei in papillary hyperplasia, positive nu clei were found in all cases of papillary adenocarcinoma. Considering these immunohistochemical results, papillary adenocarcinoma can be sai d to originate in the glandular epithelium of the prostate, as does or dinary prostatic carcinoma. (C) 1995 Wiley-Liss, Inc.