S. Glickman et al., INTRAVESICAL ATROPINE AND SUPPRESSION OF DETRUSOR HYPERCONTRACTILITY IN THE NEUROPATHIC BLADDER - A PRELIMINARY-STUDY, Paraplegia, 33(1), 1995, pp. 36-39
Twelve patients with detrusor hypercontractility secondary to spinal c
ord lesions were treated with intravesical atropine sulphate. Five pat
ients expelled the solution almost immediately. In the seven patients
who retained the solution the cystometric capacity increased by a mean
of 301 ml (P < 0.01). The volume at which an unstable contraction occ
urred increased by a mean of 190 ml (P < 0.05) and the volume at which
a urinary leak occurred increased by a mean of 297 ml (P < 0.05). The
maximum hyperreflexic detrusor contraction pressure was reduced by a
mean of 24 cm water (P < 0.05). No significant reduction in end fill p
ressure or compliance was observed though the increase in compliance a
pproached significance. No side effects were observed and no differenc
es were observed in pupillary reactions, blood pressure or pulse after
the instillation of atropine.