ENANTIOSELECTIVE SYNTHESES OF (S)-3-HYDROXYPYRROLIDIN-2-ONE AND (R)-3-HYDROXYPYRROLIDIN-2-ONE VIA LACTATE-DEHYDROGENASE CATALYZED REDUCTIONS OF 4-BENZYLOXYCARBONYLAMINO-2-OXOBUTANOIC ACID

Authors
BENTLEY JM WADSWORTH HJ WILLIS CL
Citation
Jm. Bentley et al., ENANTIOSELECTIVE SYNTHESES OF (S)-3-HYDROXYPYRROLIDIN-2-ONE AND (R)-3-HYDROXYPYRROLIDIN-2-ONE VIA LACTATE-DEHYDROGENASE CATALYZED REDUCTIONS OF 4-BENZYLOXYCARBONYLAMINO-2-OXOBUTANOIC ACID, Journal of the Chemical Society, Chemical Communications, (2), 1995, pp. 231-232
Citations number
16
Categorie Soggetti
Chemistry
Journal title
Journal of the Chemical Society, Chemical Communications → ACNP
ISSN journal
00224936
Issue
2
Year of publication
1995
Pages
231 - 232
Database
ISI
SICI code
0022-4936(1995):2<231:ESO(A(>2.0.ZU;2-E
Abstract
The first examples of the BS- and SE-lactate dehydrogenase catalysed r eductions of an alpha-keto acid incorporating a nitrogen containing fu nction in the side chain are described: (S)- and (R)-benzyloxycarbonyl amino-2-hydroxybutanoic acids were prepared in good yield and excellen t enantioselectivities and were converted to the (S)- and (R)-3-hydrox ypyrrolidin-2-ones respectively.