This paper deals with problems concerning missing data in clinical dat
abases. After signalling some shortcomings of popular solutions to inc
omplete data problems, we outline the concepts behind multiple imputat
ion. Multiple imputation is a statistically sound method for handling
incomplete data. Application of multiple imputation requires a lot of
work and not every user is able to do this. A transparent implementati
on of multiple imputation is necessary. Such an implementation is poss
ible in the HERMES medical workstation. A remaining problem is to find
proper imputations.