THIOALKYLATION OF NUCLEOSIDE-H-PHOSPHONATES AND ITS APPLICATION TO SOLID-PHASE SYNTHESIS OF OLIGONUCLEOTIDES

Authors
BRILL WKD
Citation
Wkd. Brill, THIOALKYLATION OF NUCLEOSIDE-H-PHOSPHONATES AND ITS APPLICATION TO SOLID-PHASE SYNTHESIS OF OLIGONUCLEOTIDES, Tetrahedron letters, 36(5), 1995, pp. 703-706
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
36
Issue
5
Year of publication
1995
Pages
703 - 706
Database
ISI
SICI code
0040-4039(1995)36:5<703:TONAIA>2.0.ZU;2-6
Abstract
A facile method for the thioalkylation of H-phosphonate diesters is pr esented. It can be used in the solid phase synthesis of oligonucleotid es according to the H-phosphonate method.