ADDITIVE EFFECT OF CLARITHROMYCIN COMBINED WITH 14-HYDROXY CLARITHROMYCIN, ERYTHROMYCIN, AMOXICILLIN, METRONIDAZOLE OR OMEPRAZOLE AGAINST HELICOBACTER-PYLORI

Authors
CEDERBRANT G KAHLMETER G SCHALEN C KAMME C
Citation
G. Cederbrant et al., ADDITIVE EFFECT OF CLARITHROMYCIN COMBINED WITH 14-HYDROXY CLARITHROMYCIN, ERYTHROMYCIN, AMOXICILLIN, METRONIDAZOLE OR OMEPRAZOLE AGAINST HELICOBACTER-PYLORI, Journal of antimicrobial chemotherapy, 34(6), 1994, pp. 1025-1029
Citations number
11
Categorie Soggetti
Microbiology,"Pharmacology & Pharmacy
Journal title
Journal of antimicrobial chemotherapy → ACNP
ISSN journal
03057453
Volume
34
Issue
6
Year of publication
1994
Pages
1025 - 1029
Database
ISI
SICI code
0305-7453(1994)34:6<1025:AEOCCW>2.0.ZU;2-8
Abstract
The in-vitro activities of clarithromycin, 14-OH clarithromycin, eryth romycin, amoxycillin, metronidazole and omeprazole against Helicobacte r pylori were determined at pH 7.2 and 5.5. At pH 5.5 the activities o f clarithromycin and erythromycin decreased approximately 16 times whi le 14-OH clarithromycin was less influenced. Chequerboard titration in dicated that the combined activity of clarithromycin and the other com pounds was additive.