SYNTHESIS, PLATELET ANTI-AGGREGATING ACTIVITY AND ANTIINFLAMMATORY ACTIVITY OF A SERIES OF BETA-AMINOXYPROPIONIC ACIDS

This paper reports the platelet anti-aggregating activity induced by a rachidonic acid (AA) and by adenosine-diphosphate (ADP), together with the anti-inflammatory activity evaluated by the carrageenan-induced r at paw edema method, of a series of beta-aminoxypropionic acids which were projected and synthesised as analogues of non-steroidal anti-infl ammatory drugs with an arylacetic structure B, in which the aromatic g roup is substituted by a methyleneaminoxymethylic moiety. Some of the beta-aminoxypropionic acids were evaluated for their capacity to inhib it the cyclooxygenase enzyme by measuring the malondialdehyde (MDA) pr oduced by incubation of sodium arachidonate with platelet-rich plasma (PRP).