HALOGENATED ISONIAZID DERIVATIVES AS POSSIBLE ANTIMYCOBACTERIAL AND ANTI-HIV AGENTS .3.

As part of a research directed to the synthesis of novel isoniazid der ivatives with potential activity on mycobacteria and HIV virus, the ac etophenone-isonicotinoylhydrazones 3 and the l-1-methoxy-1-(4-pyridyl) -2,3-diaza-1,3-butadienes 5, obtained by reaction between isonicotinoy lhydrazones and diazomethane, have been prepared and tested for such a ctivities. Both classes of derivatives showed interesting growth inhib itory activity on non-tubercular mycobacteria, including the emerging M. avium. Such activity appears to be linked to fluorine and/or chlori ne presence on benzene rings. In contrast, none of the compounds submi tted to the anti-AIDS in vitro screening, displayed any protection aga inst HIV-1 virus-induced cytopathic effect in T-4-lymphocyte cell line s.