COMPARISON OF 2 DOSE PREDICTION MODELS FOR CISPLATIN

Cisplatin toxicity could be decreased by adjusting its dosage to each patient. For this purpose, a limited sampling method was established a nd validated based on a Bayesian approach taken using the values of as says during a 5-day continuous infusion of cisplatin. Using this metho d, a dosing model to achieve a target plasma concentration of total pl atinum (Pt) was evaluated retrospectively; the calculated dose of cisp latin was 95.0 to 104.8% of the actual dose. This model was then studi ed prospectively and the actual plasma Pt concentration reached at the end of the infusion was 94.9% of the target concentration A strong co rrelation was observed between the clearance of Pt and the calculated clearance of creatinine or Cockroft index (p = 1.7 x 10(-11)), and thi s correlation was used to develop another cisplatin dosing model. With this model the actual concentration reached at the end of the infusio n was 85.3% of the theoretical concentration. The Bayesian approach ga ve reliable results for most clinical uses, whereas the creatinine bas ed model has to be improved.