Jd. Brierley et al., ADENOCARCINOMA OF THE RECTUM TREATED BY RADICAL EXTERNAL RADIATION-THERAPY, International journal of radiation oncology, biology, physics, 31(2), 1995, pp. 255-259
Citations number
13
Categorie Soggetti
Oncology,"Radiology,Nuclear Medicine & Medical Imaging
Purpose: To assess the long-term survival and response rates of patien
ts with primary rectal cancer to radical radiation therapy. Methods an
d Materials: Between 1978 and 1987, 229 patients were treated at the P
rincess Margaret Hospital with radical external radiation therapy for
adenocarcinoma of the rectum. Patients were treated with radiation eit
her because they were considered to have unresectable tumors, were med
ically unfit, or refused surgery, or for a combination of these factor
s. Doses ranged from 40 Gy in 10 fractions by a split course over 6 we
eks to 60 Gy in 30 fractions in 6 weeks. The most commonly prescribed
treatment was 52 Gy target absorbed dose in 20 daily fractions over 4
weeks. Results: The overall 5-year actuarial survival rate was 27%; fo
r patients with mobile tumors, it was 48%, partially fixed 27%, and fi
xed tumor 4%. Forty-eight of the 97 patients (50%) with mobile tumors,
11 of the 37 patients (30%) with partially fixed tumors, and 7 of the
77 patients (9%) with fixed tumors had clinically complete tumor regr
ession following radiation. Of these, 18 of the mobile, 6 of the parti
ally fixed, and 5 of the fixed tumors later relapsed locally. Fifty pa
tients had salvage surgery after failing to achieve complete remission
or for local relapse, with a 5-year actuarial survival rate of 42% fr
om the time of surgery. Conclusion: Although radiation therapy can cur
e some patients with mobile or partially fixed rectal adenocarcinomas
who refuse or are unsuitable for surgery, local control remains a prob
lem; salvage surgery should be considered in patients who relapse or f
ail to go into complete remission and who are fit to undergo surgery.
For patients with fixed rectal cancers, high-dose external-beam radiat
ion should be part of a planned preoperative regimen or be palliative
in intent.