DETECTION OF CARDIOVASCULAR CALCIFIED DEPOSITS VIA TETRACARBOXYLATE ION DYE (BTC) PROBING AND LASER-INDUCED FLUORESCENCE SPECTROSCOPY

Citation
Tg. Papazoglou et al., DETECTION OF CARDIOVASCULAR CALCIFIED DEPOSITS VIA TETRACARBOXYLATE ION DYE (BTC) PROBING AND LASER-INDUCED FLUORESCENCE SPECTROSCOPY, Journal of photochemistry and photobiology.B, Biology, 27(1), 1995, pp. 81-84
Citations number
7
Categorie Soggetti
Biophysics,Biology
ISSN journal
10111344
Volume
27
Issue
1
Year of publication
1995
Pages
81 - 84
Database
ISI
SICI code
1011-1344(1995)27:1<81:DOCCDV>2.0.ZU;2-T
Abstract
In order to develop a reliable, laser-induced, fluorescence-guided, an gioplasty system, fluorescence spectra were recorded during exposure o f normal and atherosclerotic cadaveric aortic tissue to argon ion lase r irradiation. A characteristic increase in the fluorescence signal in the 520-560 nm spectral region for atheromatous tissue was observed a fter treatment of the samples with a tetracarboxylate ion dye (BTC). T his allowed the development of a simple algorithm (based on the intens ity difference) and a subsequent index of discrimination between norma l and atheromatous tissue. Our results suggest that monitoring of this index through the catheter could enhance selective ablation.