Tg. Papazoglou et al., DETECTION OF CARDIOVASCULAR CALCIFIED DEPOSITS VIA TETRACARBOXYLATE ION DYE (BTC) PROBING AND LASER-INDUCED FLUORESCENCE SPECTROSCOPY, Journal of photochemistry and photobiology.B, Biology, 27(1), 1995, pp. 81-84
In order to develop a reliable, laser-induced, fluorescence-guided, an
gioplasty system, fluorescence spectra were recorded during exposure o
f normal and atherosclerotic cadaveric aortic tissue to argon ion lase
r irradiation. A characteristic increase in the fluorescence signal in
the 520-560 nm spectral region for atheromatous tissue was observed a
fter treatment of the samples with a tetracarboxylate ion dye (BTC). T
his allowed the development of a simple algorithm (based on the intens
ity difference) and a subsequent index of discrimination between norma
l and atheromatous tissue. Our results suggest that monitoring of this
index through the catheter could enhance selective ablation.