STRUCTURES AND CONFORMATION OF ANTITUMOR CYCLIC PENTAPEPTIDES, ASTIN-A, ASTIN-B AND ASTIN-C, FROM ASTER-TATARICUS

Authors
MORITA H NAGASHIMA S TAKEYA K ITOKAWA H IITAKA Y
Citation
H. Morita et al., STRUCTURES AND CONFORMATION OF ANTITUMOR CYCLIC PENTAPEPTIDES, ASTIN-A, ASTIN-B AND ASTIN-C, FROM ASTER-TATARICUS, Tetrahedron, 51(4), 1995, pp. 1121-1132
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
51
Issue
4
Year of publication
1995
Pages
1121 - 1132
Database
ISI
SICI code
0040-4020(1995)51:4<1121:SACOAC>2.0.ZU;2-4
Abstract
Astins A, B and C, three antitumour chlorine-containing cyclic pentape ptides were isolated from Aster tataricus and their structures were el ucidated by spectroscopic and chemical evidences. Astins A and B, each containing an allo threonine at residues 5 and 2, respectively, and b oth of which were isomers: showed more potent antitumour activity than astin C. Conformational analysis of astin B in solid state was conduc ted by X-ray crystallographic analysis, showing a cis configuration in one of the amide bonds.