EFFECTS OF MK-801 AND PHENYTOIN ON FLUROTHYL-INDUCED SEIZURES DURING DEVELOPMENT

Citation
L. Velisek et al., EFFECTS OF MK-801 AND PHENYTOIN ON FLUROTHYL-INDUCED SEIZURES DURING DEVELOPMENT, Epilepsia, 36(2), 1995, pp. 179-185
Citations number
36
Categorie Soggetti
Clinical Neurology
Journal title
ISSN journal
00139580
Volume
36
Issue
2
Year of publication
1995
Pages
179 - 185
Database
ISI
SICI code
0013-9580(1995)36:2<179:EOMAPO>2.0.ZU;2-Y
Abstract
We determined the effects of the N-methyl-D-aspartate (NMDA) receptor blocker MK-801 (0.05, 0.1, and 0.5 mg/kg intraperitoneally, i.p.) and phenytoin (PHT, 5, 10, and 20 mg/kg i.p.) on flurothyl-induced clonic and tonic-clonic seizures in 9-, 15-, 30-, and 60-day-old male rats. B oth agents had seizure-, age-, and dose-specific effects. The highest dose of MK-801 was anticonvulsant against clonic flurothyl-induced sei zures only in 9- and 60-day-old rats, but suppressed tonic-clonic seiz ures in all ages. The lowest dose of MK-801 (0.05 mg/kg) produced sign ificant anticonvulsant effects only in 15 day old rats. PHT did not ha ve any effect on clonic seizures throughout development. Both doses of PHT (10 and 20 mg/kg) were anticonvulsant against tonic-clonic seizur es in adult rats but not in any other age group. The results indicate that NMDA receptors play an important role in tonic-clonic flurothyl-i nduced seizures throughout development (especially in 15-day-old rats) and that the anticonvulsant effects of PHT may vary at different stag es of brain development.