QUANTITATIVE MULTICOMPONENT ANALYSIS OF ASPIRIN AND SALICYLIC-ACID INTABLETS WITHOUT SEPARATION OF EXCIPIENTS BY MEANS OF PRINCIPAL COMPONENT REGRESSION AND A CLASSICAL LEAST-SQUARES ALGORITHM
Pc. Schmidt et Bw. Glombitza, QUANTITATIVE MULTICOMPONENT ANALYSIS OF ASPIRIN AND SALICYLIC-ACID INTABLETS WITHOUT SEPARATION OF EXCIPIENTS BY MEANS OF PRINCIPAL COMPONENT REGRESSION AND A CLASSICAL LEAST-SQUARES ALGORITHM, TrAC. Trends in analytical chemistry, 14(2), 1995, pp. 45-49
Two multicomponent UV spectrophotometric methods utilizing principal c
omponent regression (PCR)and a classical least squares algorithm (CLS)
have been compared for the simultaneous analysis of aspirin (ASA) and
salicylic acid (SA) in pharmaceutical tablet preparations. The UV spe
ctra were recorded from turbid solutions without separation of interfe
ring excipients. The methods were applied to laboratory mixtures and c
ommercial tablet formulations containing ASA and SA. The multicomponen
t methods were equivalent for accuracy and precision. The results of b
oth methods were comparable to those from a conventional high-performa
nce liquid chromatographic method.