QUANTITATIVE MULTICOMPONENT ANALYSIS OF ASPIRIN AND SALICYLIC-ACID INTABLETS WITHOUT SEPARATION OF EXCIPIENTS BY MEANS OF PRINCIPAL COMPONENT REGRESSION AND A CLASSICAL LEAST-SQUARES ALGORITHM

Citation
Pc. Schmidt et Bw. Glombitza, QUANTITATIVE MULTICOMPONENT ANALYSIS OF ASPIRIN AND SALICYLIC-ACID INTABLETS WITHOUT SEPARATION OF EXCIPIENTS BY MEANS OF PRINCIPAL COMPONENT REGRESSION AND A CLASSICAL LEAST-SQUARES ALGORITHM, TrAC. Trends in analytical chemistry, 14(2), 1995, pp. 45-49
Citations number
8
Categorie Soggetti
Chemistry Analytical
ISSN journal
01659936
Volume
14
Issue
2
Year of publication
1995
Pages
45 - 49
Database
ISI
SICI code
0165-9936(1995)14:2<45:QMAOAA>2.0.ZU;2-L
Abstract
Two multicomponent UV spectrophotometric methods utilizing principal c omponent regression (PCR)and a classical least squares algorithm (CLS) have been compared for the simultaneous analysis of aspirin (ASA) and salicylic acid (SA) in pharmaceutical tablet preparations. The UV spe ctra were recorded from turbid solutions without separation of interfe ring excipients. The methods were applied to laboratory mixtures and c ommercial tablet formulations containing ASA and SA. The multicomponen t methods were equivalent for accuracy and precision. The results of b oth methods were comparable to those from a conventional high-performa nce liquid chromatographic method.