DETECTION AND QUANTIFICATION OF BIOMOLECULAR INTERACTIONS WITH OPTICAL BIOSENSORS

Optical biosensors have the potential for rapid detection and quantifi cation of the interactions between a wide range of biomolecules and ma cromolecular complexes. A new biosensor system which incorporates a re sonant mirror (RM) as the optical sensor is described, and the results obtained with it from a number of biomolecular interaction experiment s are compared with those found using another system in which the sens or is based on the surface plasmon resonance (SPR) effect. Both sets o f results are compared with those obtained using classical procedures, It is concluded that optical biosensor systems will in future probabl y provide the method of choice for studying biomolecular interactions.