NEONATAL HEPATITIS AND EXCESSIVE HEPATIC IRON DEPOSITION FOLLOWING INTRAUTERINE BLOOD-TRANSFUSION

The management of hemolytic disease has undergone a number of signific ant changes over the past few decades. Intrauterine transfusion therap y, particularly intravascular transfusions, have significantly reduced the morbidity and mortality associated with isoimmunization. This the rapy results not only in the transfusion of blood, but also in the tra nsfusion of iron. The long-term consequences of iron loading in the fe tus are unknown. We report a case of a newborn with Rh hemolytic disea se who was treated with in utero transfusions and subsequently develop ed liver disease consistent with iron overload.