SIMULTANEOUS ONSET OF VOGT-KOYANAGI-HARADA SYNDROME IN MONOZYGOTIC TWINS

PURPOSE/METHODS: We examined monozygotic twins of Vietnamese ancestry in whom the Vogt-Koyanagi-Harada syndrome developed. RESULTS/CONCLUSIO NS: Both patients demonstrated typical-clinical findings of the Vogt-K oyanagi-Harada syndrome, and HLA typing disclosed HLA-DR4, an antigen that is present in a disproportionate number of patients with the Vogt -Kopanagi-Hgrada syndrome. Although familial cases of the Vogt-Koyanag i-Harada syndrome are rare, associations with HLA antigens may indicat e that genetic factors play a role in this disease.