SCH-51048, A NOVEL BROAD-SPECTRUM ORALLY-ACTIVE ANTIFUNGAL AGENT - SYNTHESIS AND PRELIMINARY STRUCTURE-ACTIVITY PROFILE

Authors
SAKSENA AK GIRIJAVALLABHAN VM LOVEY RG DESAI JA PIKE RE JAO E WANG HY GANGULY AK LOEBENBERG D HARE RS CACCIAPUOTI A PARMEGIANI RM
Citation
Ak. Saksena et al., SCH-51048, A NOVEL BROAD-SPECTRUM ORALLY-ACTIVE ANTIFUNGAL AGENT - SYNTHESIS AND PRELIMINARY STRUCTURE-ACTIVITY PROFILE, Bioorganic & medicinal chemistry letters, 5(2), 1995, pp. 127-132
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
2
Year of publication
1995
Pages
127 - 132
Database
ISI
SICI code
0960-894X(1995)5:2<127:SANBOA>2.0.ZU;2-2
Abstract
Synthesis of Sch 51048, a novel orally active azole antifungal, is des cribed. Based on its superior oral efficacy over other available agent s against a variety of fungal pathogens in normal and immunocompromise d animal infection models, Sch 51048 is a subject for possible clinica l evaluation.