ACYL COA-CHOLESTEROL ACYLTRANSFERASE (ACAT) INHIBITORS - UREAS BEARING HETEROCYCLIC GROUPS BIOISOSTERIC FOR AN IMIDAZOLE

Authors
WILDE RG BILLHEIMER JT GERMAIN SJ GILLIES PJ HIGLEY CA KEZAR HS MADUSKUIE TP SHIMSHICK ES WEXLER RR
Citation
Rg. Wilde et al., ACYL COA-CHOLESTEROL ACYLTRANSFERASE (ACAT) INHIBITORS - UREAS BEARING HETEROCYCLIC GROUPS BIOISOSTERIC FOR AN IMIDAZOLE, Bioorganic & medicinal chemistry letters, 5(2), 1995, pp. 167-172
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
2
Year of publication
1995
Pages
167 - 172
Database
ISI
SICI code
0960-894X(1995)5:2<167:ACA(I->2.0.ZU;2-G
Abstract
A series of compounds bearing heterocyclic substituents were prepared, and evaluated for inhibition of the ACAT enzyme. The heterocyclic gro ups were compared in terms of in vitro potency against their diarylimi dazole analogues. Data for the purposes of QSAR were also collected. O ur goal is a systemic ACAT inhibitor, which would be a potential antih ypercholesterolemic and antiatherosclerotic agent.