REGIOSELECTIVE O-DEMETHYLATION OF APORPHINES WITH METHANESULFONIC-ACID METHIONINE - AN EFFICIENT ONE-POT TRANSFORMATION OF THEBAINE TO (R)(-)-2-METHOXYAPOMORPHINE

Authors
BERENYI S CSUTORAS C GYULAI S MAKLEIT S
Citation
S. Berenyi et al., REGIOSELECTIVE O-DEMETHYLATION OF APORPHINES WITH METHANESULFONIC-ACID METHIONINE - AN EFFICIENT ONE-POT TRANSFORMATION OF THEBAINE TO (R)(-)-2-METHOXYAPOMORPHINE, Synthetic communications, 25(3), 1995, pp. 283-288
Citations number
5
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthetic communications → ACNP
ISSN journal
00397911
Volume
25
Issue
3
Year of publication
1995
Pages
283 - 288
Database
ISI
SICI code
0039-7911(1995)25:3<283:ROOAWM>2.0.ZU;2-P
Abstract
2-Methoxyapomorphine (4) was obtained by the rearrangement of thebaine (1) with methanesulfonic acid in the presence of methionine, a reagen t system suitable for the regioselective O-demethylation of aporphine derivatives.