Lw. Deady et Nh. Quazi, ACETYLATION OF ALPHA-CYANO-OMICRON-TOLUNITRILE - A REINVESTIGATION AND CONVENIENT SYNTHESIS OF ISOQUINOLINES, Synthetic communications, 25(3), 1995, pp. 309-320
The product from the diacetylation of alpha-cyano-o-tolunitrile has no
w been assigned as an isocoumarin derivative. This is readily transfor
med into various 1-substituted-3-methylisoquinoline-4-carbonitriles by
reaction with oxygen, nitrogen, carbon and hydrogen nucleophiles.