AN EFFICIENT SYNTHESIS OF 4-HYDROXY-1H-INDOLE-2-CARBONITRILE AND ITS CONVERSION TO DPI-201-106

Authors
ESTEP KG
Citation
Kg. Estep, AN EFFICIENT SYNTHESIS OF 4-HYDROXY-1H-INDOLE-2-CARBONITRILE AND ITS CONVERSION TO DPI-201-106, Synthetic communications, 25(4), 1995, pp. 507-514
Citations number
24
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthetic communications → ACNP
ISSN journal
00397911
Volume
25
Issue
4
Year of publication
1995
Pages
507 - 514
Database
ISI
SICI code
0039-7911(1995)25:4<507:AESO4A>2.0.ZU;2-W
Abstract
A three-step synthesis of 4-hydroxy-1H-indole-2-carbonitrile (3) from commercially available 1,5,6,7-tetrahydro-4H-indol-4-one (4) via cyana tion and subsequent halogenation/dehydrohalogenation proceeds in 84% o verall yield. The conversion of 3 into positive inotrope DPI 201-106 ( 1) is also described.