LOW-LEVEL RESISTANCE TO THE CEPHALOSPORIN 3'-QUINOLONE ESTER RO-23-9424 IN ESCHERICHIA-COLI

Authors
CHAPMAN JS BERTASSO A CUMMINGS LM GEORGOPAPADAKOU NH
Citation
Js. Chapman et al., LOW-LEVEL RESISTANCE TO THE CEPHALOSPORIN 3'-QUINOLONE ESTER RO-23-9424 IN ESCHERICHIA-COLI, Antimicrobial agents and chemotherapy, 39(2), 1995, pp. 564-566
Citations number
16
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
39
Issue
2
Year of publication
1995
Pages
564 - 566
Database
ISI
SICI code
0066-4804(1995)39:2<564:LRTTC3>2.0.ZU;2-C
Abstract
Four spontaneous, single-step mutants of Escherichia coli K-12 resista nt to low levels of the cephalosporin 3'-quinolone ester Ro 23-9424 we re isolated at a frequency of 10(-10) to 10(-11) mutants per CFU plate d, The mutants were cross-resistant to both cephalosporin (cefotaxime) and quinolone (fleroxacin) components. Accordingly, they had altered porins and replicative DNA biosynthesis resistant to fleroxacin. There was no increase in beta-lactamase activity when tested with nitroceph in, and the penicillin-binding protein profiles were normal.