A CORRELATIVE APPROACH FOR THE IDENTIFICATION OF ANTIMUTAGENS THAT DEMONSTRATE CHEMOPREVENTIVE ACTIVITY

Seventy natural and synthetic compounds were tested for potential to i nhibit mutation induced by 7,12-dimethylbenz(a)anthracene (DMBA) in Sa lmonella typhimurium strain TM677. Results were compared with their ab ility to inhibit DMBA-induced preneoplastic lesions in a mouse mammary gland organ culture system. The response mediated by fifty-five of th e test compounds was either positive or negative in both test systems, indicating that the combined use of these assays should aid in the di scovery of antimutagenic agents that have cancer chemopreventive poten tial.