CYTOGENETICAL OBSERVATIONS AND HORMONE-RECEPTOR EXPRESSION IN 5 EXTRAUTERINE LEIOMYOMAS

The chromosomes were studied by an in vitro technique in four parametr ial and one gastric leiomyomas. The findings in parametrial myomas (th e present four cases and one published earlier) differed from the obse rvations in uterine cases by the absence of normal stemlines and the a bsence of 1p,6p and 7q changes. As has been shown earlier for intraocu lar melanomas, the location within an organ or organ system could be t he explanation for the chromosomal differences, The scanty data for le iomyomas in the digestive tract (the present case and two in the liter ature) suggest evolutionary patterns different from those in myomas in the genital tract. The reasons for this are unknown but differences i n hormonal sensitivity, as reflected by estrogen and progesterone rece ptor expression, might at least be a contributory factor.