EFFECT OF BOVINE GROWTH-HORMONE ADMINISTRATION ON THE PATTERN OF THYMIC INVOLUTION IN MICE

Authors
BARDAYAN Y SMALL M
Citation
Y. Bardayan et M. Small, EFFECT OF BOVINE GROWTH-HORMONE ADMINISTRATION ON THE PATTERN OF THYMIC INVOLUTION IN MICE, Thymus, 23(2), 1994, pp. 95-101
Citations number
11
Categorie Soggetti
Immunology
Journal title
Thymus → ACNP
ISSN journal
01656090
Volume
23
Issue
2
Year of publication
1994
Pages
95 - 101
Database
ISI
SICI code
0165-6090(1994)23:2<95:EOBGAO>2.0.ZU;2-1
Abstract
Age-related decline of the thymus in mice was reversed by repeated inj ections of bovine growth hormone. After hormone administration that wa s begun at 5, 8, or 11.5 months of age, the cortical volume fraction ( Vc), cortical/medullary ratio (C/M) and thymocyte numbers found were i n the range obtained with younger mice. Growth hormone injection reduc ed the slope of the curves for Vc and C/M as a function of age, indica ting a slowing down of the involution process.