CYTOKINE MODULATION OF INTERLEUKIN-1 AND TUMOR-NECROSIS-FACTOR-ALPHA SECRETION FROM ACUTE MYELOGENOUS LEUKEMIA BLAST CELLS IN-VITRO

Spontaneous secretion of interleukin 1 (IL-1)alpha, IL-1 beta and tumo ur necrosis factor-alpha (TNF-alpha) from acute myelogenous leukaemia (AML) blasts showed significant correlation, and detectable levels of all cytokines were seen for a majority of patients. IL-3 and granulocy te/macrophage colony-stimulating factor increased secretion of IL-1 al pha, IL-1 beta and TNF-alpha for a majority of AML patients, whereas I L-4 decreased cytokine secretion. The effect of IL-6 and stem cell fac tor on cytokine secretion varied between different patients. A wide va riation in IL-1 alpha, IL-1 beta and TNF-alpha secretion between diffe rent patients was seen both for spontaneous secretion and in the prese nce of all cytokines.