MACROMOLECULAR PRODRUGS .4. ALGINATE-CHITOSAN MICROSPHERES OF PHEA-L-DOPA ADDUCT

Authors
FILIPOVICGRCIC J MAYSINGER D ZORC B JALSENJAK I
Citation
J. Filipovicgrcic et al., MACROMOLECULAR PRODRUGS .4. ALGINATE-CHITOSAN MICROSPHERES OF PHEA-L-DOPA ADDUCT, International journal of pharmaceutics, 116(1), 1995, pp. 39-44
Citations number
11
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
International journal of pharmaceutics → ACNP
ISSN journal
03785173
Volume
116
Issue
1
Year of publication
1995
Pages
39 - 44
Database
ISI
SICI code
0378-5173(1995)116:1<39:MP.AMO>2.0.ZU;2-#
Abstract
A polymeric prodrug ha,beta-poly(N-hydroxyethyl)-DL-aspartamide-L-dopa adduct (PHEA-L-dopa) was microencapsulated in alginate-chitosan micro spheres in order to achieve drug release from a complex reservoir devi ce. The gel/matrix material of alginate-chitosan complex protects the adduct from hydrolysis by the surrounding medium. On the basis of a 10 (3)-fold difference between the drug released from microspheres as the adduct and that released in the unbound form, a model of the microenc apsulated system was proposed.