Pars planitis is an intraocular inflammatory disorder which usually af
fects children or young adults and is characterized by vitreous cells
and debris ('snowballs'), exudate, and 'snowbank' formation along the
pars plana, variable periphlebitis, and cystoid macular edema. Althoug
h no inheritance pattern has been defined, familial cases of pars plai
nitis have been reported. This report describes pars planitis in two s
isters, one of whom had evidence of demyelinating disease at presentat
ion. The literature on familial pars planitis is reviewed. To the auth
or's knowledge this is the first case of familial pars planitis as the
presenting sign of possible demyelinating disease.