PROTECTION OF GOATS AGAINST PESTE DES PETITS RUMINANTS WITH RECOMBINANT CAPRIPOXVIRUSES EXPRESSING THE FUSION AND HEMAGGLUTININ PROTEIN GENES OF RINDERPEST VIRUS

Authors
ROMERO CH BARRETT T KITCHING RP BOSTOCK C BLACK DN
Citation
Ch. Romero et al., PROTECTION OF GOATS AGAINST PESTE DES PETITS RUMINANTS WITH RECOMBINANT CAPRIPOXVIRUSES EXPRESSING THE FUSION AND HEMAGGLUTININ PROTEIN GENES OF RINDERPEST VIRUS, Vaccine, 13(1), 1995, pp. 36-40
Citations number
12
Categorie Soggetti
Immunology
Journal title
Vaccine → ACNP
ISSN journal
0264410X
Volume
13
Issue
1
Year of publication
1995
Pages
36 - 40
Database
ISI
SICI code
0264-410X(1995)13:1<36:POGAPD>2.0.ZU;2-O
Abstract
Goats were protected against a lethal challenge of peste des petits ru minants (PPR) virus following vaccination with a recombinant capripoxv irus containing either the fusion (F) gene of rinderpest virus or the haemagglutinin (H) gene of rinderpest virus. The H gene recombinant pr oduced high titres of neutralizing antibody to rinderpest virus in the vaccinated goats, whereas the F gene recombinant failed to stimulate detectable levels of neutralizing antibody. A similar response to the two recombinant vaccines has previously been reported for cattle. Neit her recombinant produced detectable levels of specific antibodies to P PR virus.